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With nearly 2830% weight reduction, retatrutide is no longer just competing with GLP-1 therapies it is challenging the very biology of obesity itself

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The side effects of GLP-1 agonists are most commonly gastrointestinal in nature

doi: 10.3389/fmed.2022.875430 Summary Keywords glucagon-like peptide-1 receptor agonist (GLP-1RA), incretin based therapy, glucose-depent insulinotropic peptide (GIP), dual agonists, tirzepatide, type 2 diabetes Citation Gallwitz B (2022) Clinical perspectives on the use of the GIP/GLP-1 receptor agonist tirzepatide for the treatment of type-2 diabetes and obesity